Season
- Season 0 2012-08-26
- Season 1 2009-07-16
- Season 2 2010-01-14
- Season 3 2010-09-09
- Season 5 2011-09-25
- Season 6 2012-01-08
- Season 7 2012-06-17
- Season 8 2012-09-09
- Season 9 2013-01-06
- Season 10 2013-06-16
- Season 11 2014-01-05
- Season 12 2015-01-04
- Season 13 2016-01-03
- Season 14 2017-01-03
- Season 15 2018-01-07
- Season 16 2019-01-06
- Season 17 2020-01-05
- Season 18 2021-01-03
- Season 19 2022-01-05
- Season 20 2023-01-02
- Season 21 2024-01-07
Episode
- Episode 1: Robyn Dixon, Dr. Simone Whitmore
- Episode 2: Max Salvador, Lily Davison
- Episode 3: Busy Philipps, Dan Levy
- Episode 4: Lisa Hochstein, Larsa Pippen
- Episode 5: Kevin Hart
- Episode 6: Gizelle Bryant & Renee Rapp
- Episode 7: Jack Luby & Luka Brunton
- Episode 8: Mercedes "MJ" Javid & Jeff Lewis
- Episode 9: Erika Jayne & Dr. Nicole Martin
- Episode 10: Southern Charm: Leva, Austen & Craig
- Episode 11: Candiace Dillard Bassett & Phaedra Parks
- Episode 12: Capt. Sandy Yawn & Tumi Mhlongo
- Episode 13: Heather Gay & Joel Kim Booster
- Episode 14: Alexia Nepola & Sofia Vergara
- Episode 15: Luann De Lesseps & Joe Bradley
- Episode 16: Nneka Ihim and Lateasha Lunceford
- Episode 17: Kate Chastain and Chrissy Teigen
- Episode 18: Lala Kent and Michael Rapaport
- Episode 19: Annemarie Wiley and Chloe Fineman
- Episode 20: Catherine O'Hara and Bryan Cranston
- Episode 21: Ashley Darby and Dr. Alicia Egolum
- Episode 22: Captain Kerry Titheradge and Fraser Olender
- Episode 23: Scheana Shay and Ryan Serhant
- Episode 24: Sutton Stracke and Kaitlan Collins
- Episode 25: Alan Cumming & Darren Criss
- Episode 26: Janelle James and Dylan McDermott
- Episode 27: Maddi Reese and James Kennedy
- Episode 28: Adriana De Moura and Julia Lemigova
- Episode 29: Amy Schumer
- Episode 30: Karen Huger & Dr. Jackie Walters
- Episode 31: Da'Vine Joy Randolph & Second Gentleman Douglas Emhoff
- Episode 32: Jenna Dewan & Tom Schwartz
- Episode 33: Kyle Richards & Kiki Barth
- Episode 34: Southern Hospitality Season 2 Reunion
- Episode 35: Cush Jumbo & Gizelle Bryant
- Episode 36: Barbara “Barbie” Pascual & Jared Woodin
- Episode 37: Paige DeSorbo & Michelle Collins
- Episode 38: Cheryl Hines & Susie Essman
- Episode 39: Annaleigh Ashford & Danielle Olivera
- Episode 40: Candiace Dillard Bassett & Cynthia Bailey
- Episode 41: Kelly Ripa & Mark Consuelos
- Episode 42: Lala Kent & Ashley Tisdale
- Episode 43: Sonja Morgan & Denise Richards
- Episode 44: Lindsay Hubbard & Carson Kressley
- Episode 45: Robyn Dixon & Claudia Jordan
- Episode 46: Awkwafina & Ayesha Curry
- Episode 47: Ariana Madix & John Oliver
- Episode 48: Carrie Coon & Patton Oswalt
- Episode 49: Carl Radke & Trishelle Cannatella
- Episode 50: Dr. Wendy Osefo & Quad Webb
- Episode 51: Jenny McCarthy-Wahlberg & Ben Willoughby
- Episode 52: Katie Maloney & Lukas Gage
- Episode 53: Josh Lucas & José Andrés
- Episode 54: Kristen Wiig & Ricky Martin
- Episode 55: Mia Thornton & Leslie Bibb
- Episode 56: Nicola Coughlan & Brittany Cartwright
- Episode 57: Elizabeth Hurley & Brooke Shields
- Episode 58: Annabelle Dexter-Jones & Amanda Batula
- Episode 59: Bria Fleming & Shanice Henderson
- Episode 60: Alison Brie & Rebel Wilson
- Episode 61: Scheana Shay & Brock Davies
- Episode 62: Michaela Jae Rodriguez & Jerrod Carmichael
- Episode 63: Kyle Cooke & West Wilson
- Episode 64: Jasmine Ellis Cooper & Summer Marie Thomas
- Episode 65: Sara Bareilles & Ben Platt
- Episode 66: Kristen Doute & Tom Schwartz
- Episode 67: Pam Grier & Max Greenfield
- Episode 68: Ciara Miller & Tyler Cameron
- Episode 69: Selenis Leyva & Preston Mitchum
- Episode 70: Jennifer Tilly & Tumi Mhlongo
- Episode 71: Ally Lewber & Janet Caperna
- Episode 72: Jesse Tyler Ferguson & John Early
- Episode 73: Gabby Prescod & Lindsay Hubbard
- Episode 74: Kandi Burruss & Alex Tyree
- Episode 75: Rachael Harris & Dylan Pierre De Villiers
- Episode 76: Ariana Madix & Katie Maloney
- Episode 77: Kyra Sedgwick & Jim Gaffigan
- Episode 78: Danielle Olivera & Andrea Canning
- Episode 79: Dolores Catania & Mark Indelicato
- Episode 80: Charli XCX & Joe Manganiello
- Episode 81: Jax Taylor & Tom Sandoval
- Episode 82: Casey Wilson & Jessica St. Clair
- Episode 83: Carl Radke & Jesse Solomon
- Episode 84: Melissa Gorga & Meghan McCain
- Episode 85: Barbara Pascual & Paris Field
- Episode 86: Lisa Vanderpump & Gordan Ramsay
- Episode 87: Andra Day & Cecily Strong
- Episode 88: Patti Stanger & Amanda Batula
- Episode 89: Margaret Josephs & Nick Arrington
- Episode 90: Julia Fox & Shay Mitchell
- Episode 91: Michelle Buteau & Jesse Lally
- Episode 92: Top Chef: Gail, Kristen & Tom
- Episode 93: Kyle Cooke & Paul Scheer
- Episode 94: Summer House: Martha's Vineyard Reunion
- Episode 95: Teresa Giudice & Joel Kim Booster
- Episode 96: Captain Sandy Yawn & Jennifer Esposito
- Episode 97: Lesa Milan & Tabatha Coffey
- Episode 98: Tony Hale & Meghan Trainor
- Episode 99: James Brolin & Tony Goldwyn
- Episode 100: Jackie Goldschneider & Jennifer Fessler
- Episode 101: Aesha Scott & Elena Dubaich
- Episode 102: Caroline Stanbury & Jeff Lewis
- Episode 103: Abby Elliott & Craig Melvin
- Episode 104: Iggy Azalea & Sandra Bernhard
- Episode 105: Rachel Fuda & Heidi Gardner
- Episode 106: Bri Muller & Gael Cameron
- Episode 107: Taleen Marie & Bryan Safi
- Episode 108: Eva Longoria & Chace Crawford
- Episode 109: Jordan Klepper & Adam Lambert
- Episode 110: 15th Anniversary Special
- Episode 111: Joe Bradley & Nathan Gallagher
- Episode 112: Hoda Kotb and Savannah Guthrie
- Episode 113: Rashida Jones and Joey King
- Episode 114: Shannon Storms Beador and Kate Upton
- Episode 115: Gary Janetti and Jennifer Aydin
- Episode 116: Johnathan Shillingford and Iain Maclean
- Episode 117: Caroline Brooks and Tracy Tutor
- Episode 118: Kate Hudson Brad Goreski
- Episode 119: Jennifer Pedranti and Ryan Serhant
- Episode 120: Danielle Cabral and David Arquette
- Episode 121: Dave Bautista and Ken Jeong
- Episode 122: Lesa Milan and Alyssa Farah Griffin
- Episode 123: Cindy Crawford and Colman Domingo
Watch What Happens Live with Andy Cohen - Season 21 Episode 50 : Dr. Wendy Osefo & Quad Webb
Andy Cohen interviews Dr. Wendy Osefo & Quad Webb.
